| Year | Team | W | L | G | IP | ERA | WHIP | K | BB | HR | K/9 | BB/9 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1995 | Minnesota Twins | 2 | 3 | 6 | 27.0 | 8.67 | 1.89 | 9 | 12 | 3 | 3.00 | 4.00 |
| 1996 |
| Minnesota Twins |
| 1 |
| 1 |
| 7 |
| 26.1 |
| 8.20 |
| 1.94 |
| 24 |
| 9 |
| 8 |
| 8.20 |
| 3.08 |
| 1997 | Minnesota Twins | 6 | 12 | 20 | 103.1 | 5.84 | 1.75 | 58 | 47 | 19 | 5.05 | 4.09 |
| 1998 | Minnesota Twins | 7 | 14 | 33 | 190.1 | 5.25 | 1.51 | 105 | 61 | 27 | 4.96 | 2.88 |
| 1999 | Minnesota Twins | 10 | 14 | 33 | 174.1 | 6.66 | 1.71 | 103 | 60 | 29 | 5.32 | 3.10 |
| 2000 | Minnesota Twins | 2 | 5 | 66 | 87.2 | 3.39 | 1.33 | 59 | 32 | 7 | 6.06 | 3.29 |
| 2001 | Minnesota Twins | 1 | 5 | 62 | 51.1 | 5.96 | 1.91 | 36 | 39 | 3 | 6.31 | 6.84 |
| 2002 | Minnesota Twins | 6 | 0 | 65 | 80.1 | 2.13 | 0.97 | 63 | 15 | 5 | 7.06 | 1.68 |
| 2003 | Minnesota Twins | 9 | 3 | 74 | 77.1 | 1.86 | 1.09 | 75 | 15 | 4 | 8.73 | 1.75 |
| 2004 | Chicago Cubs | 5 | 4 | 77 | 82.0 | 2.63 | 1.05 | 69 | 14 | 10 | 7.57 | 1.54 |
| 2005 | Chicago Cubs | 1 | 4 | 21 | 19.0 | 3.32 | 1.32 | 13 | 7 | 4 | 6.16 | 3.32 |
| 2005 | San Francisco Giants | 1 | 4 | 45 | 37.1 | 4.10 | 1.53 | 30 | 17 | 3 | 7.23 | 4.10 |
| 2005 | 2 | 8 | 66 | 56.1 | 3.83 | 1.46 | 43 | 24 | 7 | 6.87 | 3.83 |
| 2006 | Baltimore Orioles | 3 | 2 | 60 | 60.1 | 4.48 | 1.46 | 27 | 15 | 4 | 4.03 | 2.24 |
| 2007 | Colorado Rockies | 2 | 5 | 62 | 55.1 | 3.42 | 1.23 | 29 | 16 | 6 | 4.72 | 2.60 |
| 2008 | New York Yankees | 1 | 1 | 33 | 41.0 | 5.71 | 1.44 | 23 | 17 | 3 | 5.05 | 3.73 |
| 2008 | Houston Astros | 2 | 0 | 24 | 21.0 | 0.43 | 0.76 | 25 | 5 | 0 | 10.71 | 2.14 |
| 2008 | 3 | 1 | 57 | 62.0 | 3.92 | 1.21 | 48 | 22 | 3 | 6.97 | 3.19 |
| 2009 | Houston Astros | 1 | 4 | 65 | 63.1 | 2.13 | 1.20 | 45 | 16 | 7 | 6.39 | 2.27 |
| 2010 | Milwaukee Brewers | 0 | 3 | 18 | 16.0 | 8.44 | 1.69 | 18 | 6 | 2 | 10.13 | 3.38 |
| 2011 | Milwaukee Brewers | 3 | 1 | 52 | 48.1 | 2.42 | 1.24 | 28 | 10 | 1 | 5.21 | 1.86 |
| 2012 | Los Angeles Angels | 2 | 3 | 48 | 42.0 | 3.64 | 1.38 | 23 | 13 | 5 | 4.93 | 2.79 |
| 2013 | New York Mets | 3 | 2 | 72 | 70.2 | 2.93 | 1.15 | 55 | 10 | 6 | 7.00 | 1.27 |
| 2014 | Colorado Rockies | 4 | 3 | 57 | 54.1 | 3.31 | 1.20 | 32 | 13 | 3 | 5.30 | 2.15 |
| 2015 | Colorado Rockies | 2 | 1 | 24 | 22.1 | 3.63 | 1.16 | 20 | 4 | 3 | 8.06 | 1.61 |
| 2015 | Toronto Blue Jays | 1 | 0 | 18 | 16.1 | 2.76 | 1.53 | 14 | 3 | 1 | 7.71 | 1.65 |
| 2015 | 3 | 1 | 42 | 38.2 | 3.26 | 1.32 | 34 | 7 | 4 | 7.91 | 1.63 |
| Career | — | 75 | 94 | 1,042 | 1467.1 | 4.31 | 1.41 | 983 | 456 | 163 | 6.03 | 2.80 |