| Year | Team | W | L | G | IP | ERA | WHIP | K | BB | HR | K/9 | BB/9 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1995 | New York Yankees | 12 | 9 | 31 | 175.0 | 4.17 | 1.41 | 114 | 63 | 15 | 5.86 | 3.24 |
| 1996 |
| New York Yankees |
| 21 |
| 8 |
| 35 |
| 221.0 |
| 3.87 |
| 1.36 |
| 162 |
| 72 |
| 23 |
| 6.60 |
| 2.93 |
| 1997 | New York Yankees | 18 | 7 | 35 | 240.1 | 2.88 | 1.24 | 166 | 65 | 7 | 6.22 | 2.43 |
| 1998 | New York Yankees | 16 | 11 | 33 | 216.1 | 4.24 | 1.45 | 146 | 87 | 20 | 6.07 | 3.62 |
| 1999 | New York Yankees | 14 | 11 | 31 | 191.2 | 4.70 | 1.59 | 121 | 89 | 20 | 5.68 | 4.18 |
| 2000 | New York Yankees | 19 | 9 | 32 | 204.2 | 4.35 | 1.46 | 125 | 80 | 17 | 5.50 | 3.52 |
| 2001 | New York Yankees | 15 | 10 | 31 | 200.2 | 3.99 | 1.32 | 164 | 41 | 14 | 7.36 | 1.84 |
| 2002 | New York Yankees | 13 | 5 | 22 | 134.2 | 3.27 | 1.31 | 97 | 32 | 6 | 6.48 | 2.14 |
| 2003 | New York Yankees | 21 | 8 | 33 | 208.1 | 4.02 | 1.33 | 180 | 50 | 21 | 7.78 | 2.16 |
| 2004 | Houston Astros | 6 | 4 | 15 | 83.0 | 3.90 | 1.23 | 79 | 31 | 8 | 8.57 | 3.36 |
| 2005 | Houston Astros | 17 | 9 | 33 | 222.1 | 2.39 | 1.03 | 171 | 41 | 17 | 6.92 | 1.66 |
| 2006 | Houston Astros | 14 | 13 | 36 | 214.1 | 4.20 | 1.44 | 178 | 70 | 27 | 7.47 | 2.94 |
| 2007 | New York Yankees | 15 | 9 | 36 | 215.1 | 4.05 | 1.43 | 141 | 69 | 16 | 5.89 | 2.88 |
| 2008 | New York Yankees | 14 | 14 | 33 | 204.0 | 4.54 | 1.41 | 158 | 55 | 19 | 6.97 | 2.43 |
| 2009 | New York Yankees | 14 | 8 | 32 | 194.2 | 4.16 | 1.38 | 148 | 76 | 20 | 6.84 | 3.51 |
| 2010 | New York Yankees | 11 | 3 | 21 | 129.0 | 3.28 | 1.27 | 101 | 41 | 13 | 7.05 | 2.86 |
| 2012 | New York Yankees | 5 | 4 | 12 | 75.1 | 2.87 | 1.14 | 69 | 21 | 8 | 8.24 | 2.51 |
| 2013 | New York Yankees | 11 | 11 | 30 | 185.1 | 3.74 | 1.33 | 128 | 48 | 17 | 6.22 | 2.33 |
| Career | — | 256 | 153 | 531 | 3316.0 | 3.85 | 1.35 | 2,448 | 1,031 | 288 | 6.64 | 2.80 |
