| Year | Team | W | L | G | IP | ERA | WHIP | K | BB | HR | K/9 | BB/9 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2000 | Atlanta Braves | 1 | 0 | 15 | 23.1 | 5.01 | 1.50 | 17 | 12 | 4 | 6.56 | 4.63 |
| 2001 |
| Atlanta Braves |
| 5 |
| 6 |
| 38 |
| 129.1 |
| 3.48 |
| 1.33 |
| 98 |
| 59 |
| 14 |
| 6.82 |
| 4.11 |
| 2002 | Atlanta Braves | 8 | 9 | 22 | 114.1 | 5.04 | 1.54 | 84 | 49 | 19 | 6.61 | 3.86 |
| 2003 | Atlanta Braves | 0 | 0 | 21 | 40.2 | 5.53 | 1.50 | 19 | 18 | 3 | 4.20 | 3.98 |
| 2004 | St. Louis Cardinals | 15 | 7 | 32 | 201.1 | 3.71 | 1.42 | 138 | 70 | 26 | 6.17 | 3.13 |
| 2005 | St. Louis Cardinals | 13 | 14 | 33 | 207.0 | 4.13 | 1.33 | 100 | 69 | 29 | 4.35 | 3.00 |
| 2006 | St. Louis Cardinals | 14 | 16 | 33 | 194.1 | 6.02 | 1.52 | 96 | 75 | 35 | 4.45 | 3.47 |
| 2007 | Chicago Cubs | 12 | 9 | 34 | 191.2 | 4.60 | 1.39 | 109 | 76 | 22 | 5.12 | 3.57 |
| 2008 | Chicago Cubs | 11 | 9 | 29 | 167.0 | 4.53 | 1.45 | 91 | 70 | 15 | 4.90 | 3.77 |
| 2009 | Colorado Rockies | 15 | 13 | 33 | 216.0 | 4.04 | 1.38 | 115 | 80 | 15 | 4.79 | 3.33 |
| 2010 | Washington Nationals | 2 | 9 | 13 | 58.2 | 6.60 | 1.70 | 31 | 24 | 9 | 4.76 | 3.68 |
| 2011 | Washington Nationals | 8 | 5 | 20 | 120.2 | 3.95 | 1.42 | 71 | 39 | 8 | 5.30 | 2.91 |
| 2011 | Arizona Diamondbacks | 0 | 1 | 3 | 11.1 | 9.53 | 2.29 | 5 | 4 | 3 | 3.97 | 3.18 |
| 2011 | 8 | 6 | 23 | 132.0 | 4.43 | 1.49 | 76 | 43 | 11 | 5.18 | 2.93 |
| 2012 | Minnesota Twins | 2 | 4 | 7 | 34.0 | 8.47 | 1.94 | 12 | 14 | 9 | 3.18 | 3.71 |
| 2012 | San Diego Padres | 6 | 7 | 15 | 93.2 | 4.04 | 1.30 | 79 | 28 | 14 | 7.59 | 2.69 |
| 2012 | 8 | 11 | 22 | 127.2 | 5.22 | 1.47 | 91 | 42 | 23 | 6.42 | 2.96 |
| 2013 | San Diego Padres | 9 | 5 | 20 | 117.2 | 4.05 | 1.52 | 72 | 68 | 18 | 5.51 | 5.20 |
| 2015 | Cincinnati Reds | 3 | 4 | 9 | 47.1 | 6.46 | 1.65 | 37 | 14 | 10 | 7.04 | 2.66 |
| Career | — | 124 | 118 | 377 | 1968.1 | 4.61 | 1.45 | 1,174 | 769 | 253 | 5.37 | 3.52 |
