| Year | Team | W | L | G | IP | ERA | WHIP | K | BB | HR | K/9 | BB/9 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2000 | Minnesota Twins | 2 | 3 | 30 | 86.0 | 6.49 | 1.81 | 64 | 54 | 11 | 6.70 | 5.65 |
| 2001 |
| Minnesota Twins |
| 1 |
| 0 |
| 15 |
| 43.2 |
| 4.74 |
| 1.51 |
| 28 |
| 16 |
| 6 |
| 5.77 |
| 3.30 |
| 2002 | Minnesota Twins | 8 | 6 | 27 | 108.1 | 2.99 | 1.23 | 137 | 49 | 7 | 11.38 | 4.07 |
| 2003 | Minnesota Twins | 12 | 3 | 45 | 158.1 | 3.07 | 1.10 | 169 | 47 | 17 | 9.61 | 2.67 |
| 2004 | Minnesota Twins | 20 | 6 | 34 | 228.0 | 2.61 | 0.92 | 265 | 54 | 24 | 10.46 | 2.13 |
| 2005 | Minnesota Twins | 16 | 7 | 33 | 231.2 | 2.87 | 0.97 | 238 | 45 | 22 | 9.25 | 1.75 |
| 2006 | Minnesota Twins | 19 | 6 | 34 | 233.2 | 2.77 | 1.00 | 245 | 47 | 24 | 9.44 | 1.81 |
| 2007 | Minnesota Twins | 15 | 13 | 33 | 219.0 | 3.33 | 1.07 | 235 | 52 | 33 | 9.66 | 2.14 |
| 2008 | New York Mets | 16 | 7 | 34 | 234.1 | 2.53 | 1.15 | 206 | 63 | 23 | 7.91 | 2.42 |
| 2009 | New York Mets | 13 | 9 | 25 | 166.2 | 3.13 | 1.21 | 146 | 46 | 20 | 7.88 | 2.48 |
| 2010 | New York Mets | 11 | 9 | 29 | 199.0 | 2.98 | 1.18 | 144 | 55 | 16 | 6.51 | 2.49 |
| 2012 | New York Mets | 6 | 9 | 21 | 117.0 | 4.85 | 1.33 | 111 | 39 | 17 | 8.54 | 3.00 |
| Career | — | 139 | 78 | 360 | 2025.2 | 3.20 | 1.13 | 1,988 | 567 | 220 | 8.83 | 2.52 |