| Year | Team | G | AB | H | HR | RBI | SB | BB | K | AVG | OBP | SLG | OPS |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2002 | Cleveland Indians | 12 | 32 | 9 | 1 | 5 | 0 | 3 | 2 | .281 | .333 | .406 |
| .739 |
| 2003 | Cleveland Indians | 49 | 159 | 46 | 1 | 16 | 1 | 13 | 21 | .289 | .345 | .333 | .678 |
| 2004 | Cleveland Indians | 141 | 520 | 147 | 23 | 108 | 0 | 60 | 69 | .283 | .359 | .492 | .851 |
| 2005 | Cleveland Indians | 147 | 547 | 167 | 20 | 80 | 0 | 63 | 78 | .305 | .378 | .475 | .853 |
| 2006 | Cleveland Indians | 153 | 572 | 181 | 16 | 93 | 0 | 71 | 78 | .316 | .391 | .465 | .856 |
| 2007 | Cleveland Indians | 147 | 562 | 169 | 25 | 114 | 0 | 62 | 76 | .301 | .374 | .505 | .879 |
| 2008 | Cleveland Indians | 73 | 266 | 74 | 2 | 35 | 0 | 24 | 32 | .278 | .337 | .365 | .702 |
| 2009 | Cleveland Indians | 99 | 377 | 107 | 15 | 67 | 0 | 51 | 51 | .284 | .368 | .464 | .832 |
| 2009 | Boston Red Sox | 56 | 211 | 71 | 8 | 41 | 1 | 24 | 23 | .336 | .405 | .507 | .912 |
| 2009 | 155 | 588 | 178 | 23 | 108 | 1 | 75 | 74 | .303 | .381 | .480 | .861 |
| 2010 | Boston Red Sox | 127 | 493 | 149 | 20 | 79 | 1 | 40 | 52 | .302 | .351 | .493 | .844 |
| 2011 | Detroit Tigers | 145 | 540 | 178 | 12 | 103 | 1 | 46 | 51 | .330 | .380 | .470 | .850 |
| 2013 | Detroit Tigers | 159 | 605 | 182 | 14 | 83 | 0 | 54 | 62 | .301 | .355 | .430 | .785 |
| 2014 | Detroit Tigers | 151 | 561 | 188 | 32 | 103 | 3 | 70 | 42 | .335 | .409 | .565 | .974 |
| 2015 | Detroit Tigers | 120 | 440 | 108 | 11 | 64 | 0 | 31 | 52 | .245 | .301 | .366 | .667 |
| 2016 | Detroit Tigers | 154 | 553 | 160 | 27 | 86 | 0 | 50 | 90 | .289 | .351 | .476 | .827 |
| 2017 | Detroit Tigers | 107 | 392 | 100 | 10 | 47 | 0 | 36 | 63 | .255 | .324 | .372 | .696 |
| 2018 | Detroit Tigers | 133 | 467 | 117 | 9 | 54 | 0 | 32 | 49 | .251 | .297 | .353 | .650 |
| Career | — | 1,973 | 7,297 | 2,153 | 246 | 1,178 | 7 | 730 | 891 | .295 | .360 | .455 | .815 |
