| Year | Team | G | AB | H | HR | RBI | SB | BB | K | AVG | OBP | SLG | OPS |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2004 | Colorado Rockies | 121 | 400 | 116 | 14 | 57 | 3 | 31 | 86 | .290 | .349 | .488 |
| .837 |
| 2005 | Colorado Rockies | 125 | 479 | 147 | 19 | 87 | 14 | 36 | 79 | .307 | .361 | .505 | .866 |
| 2006 | Colorado Rockies | 155 | 602 | 196 | 34 | 114 | 10 | 47 | 110 | .326 | .387 | .586 | .973 |
| 2007 | Colorado Rockies | 158 | 636 | 216 | 36 | 137 | 11 | 63 | 126 | .340 | .405 | .607 | 1.012 |
| 2008 | Colorado Rockies | 139 | 539 | 173 | 25 | 88 | 28 | 74 | 104 | .321 | .409 | .538 | .947 |
| 2009 | Oakland Athletics | 93 | 346 | 99 | 11 | 54 | 12 | 46 | 58 | .286 | .378 | .454 | .832 |
| 2009 | St. Louis Cardinals | 63 | 235 | 83 | 13 | 55 | 2 | 26 | 43 | .353 | .419 | .604 | 1.023 |
| 2009 | 156 | 581 | 182 | 24 | 109 | 14 | 72 | 101 | .313 | .394 | .515 | .909 |
| 2010 | St. Louis Cardinals | 158 | 596 | 186 | 28 | 103 | 9 | 69 | 93 | .312 | .390 | .532 | .922 |
| 2011 | St. Louis Cardinals | 124 | 446 | 132 | 22 | 75 | 2 | 60 | 93 | .296 | .388 | .525 | .913 |
| 2012 | St. Louis Cardinals | 157 | 599 | 177 | 27 | 102 | 4 | 75 | 132 | .295 | .379 | .497 | .876 |
| 2013 | St. Louis Cardinals | 141 | 520 | 156 | 22 | 94 | 6 | 69 | 86 | .300 | .389 | .490 | .879 |
| 2014 | St. Louis Cardinals | 156 | 574 | 156 | 20 | 90 | 4 | 74 | 100 | .272 | .370 | .441 | .811 |
| 2015 | St. Louis Cardinals | 73 | 229 | 64 | 4 | 35 | 2 | 39 | 49 | .279 | .394 | .410 | .804 |
| 2016 | St. Louis Cardinals | 110 | 382 | 94 | 20 | 62 | 0 | 35 | 71 | .246 | .322 | .461 | .783 |
| 2017 | New York Yankees | 105 | 373 | 86 | 19 | 64 | 1 | 46 | 114 | .231 | .316 | .432 | .748 |
| 2018 | Colorado Rockies | 25 | 53 | 15 | 2 | 3 | 0 | 12 | 18 | .283 | .415 | .434 | .849 |
| Career | — | 1,903 | 7,009 | 2,096 | 316 | 1,220 | 108 | 802 | 1,362 | .299 | .379 | .510 | .889 |
