| Year | Team | W | L | G | IP | ERA | WHIP | K | BB | HR | K/9 | BB/9 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2002 | Anaheim Angels | 0 | 0 | 5 | 5.2 | 0.00 | 0.88 | 13 | 2 | 0 | 20.65 | 3.18 |
| 2003 |
| Anaheim Angels |
| 8 |
| 3 |
| 59 |
| 86.0 |
| 3.03 |
| 0.99 |
| 95 |
| 35 |
| 12 |
| 9.94 |
| 3.66 |
| 2004 | Anaheim Angels | 4 | 1 | 69 | 84.0 | 1.82 | 1.00 | 123 | 33 | 2 | 13.18 | 3.54 |
| 2005 | Los Angeles Angels | 2 | 5 | 66 | 67.1 | 2.67 | 1.14 | 91 | 32 | 7 | 12.16 | 4.28 |
| 2006 | Los Angeles Angels | 2 | 3 | 69 | 73.0 | 1.73 | 1.10 | 98 | 28 | 6 | 12.08 | 3.45 |
| 2007 | Los Angeles Angels | 5 | 2 | 64 | 67.1 | 2.81 | 1.25 | 90 | 34 | 3 | 12.03 | 4.54 |
| 2008 | Los Angeles Angels | 2 | 3 | 76 | 68.1 | 2.24 | 1.29 | 77 | 34 | 4 | 10.14 | 4.48 |
| 2009 | New York Mets | 3 | 6 | 70 | 68.0 | 3.71 | 1.31 | 73 | 38 | 7 | 9.66 | 5.03 |
| 2010 | New York Mets | 4 | 2 | 53 | 57.1 | 2.20 | 1.15 | 67 | 21 | 3 | 10.52 | 3.30 |
| 2011 | New York Mets | 2 | 2 | 42 | 42.2 | 3.16 | 1.41 | 46 | 16 | 3 | 9.70 | 3.38 |
| 2011 | Milwaukee Brewers | 4 | 0 | 31 | 29.0 | 1.86 | 1.14 | 33 | 10 | 1 | 10.24 | 3.10 |
| 2011 | 6 | 2 | 73 | 71.2 | 2.64 | 1.30 | 79 | 26 | 4 | 9.92 | 3.27 |
| 2012 | Milwaukee Brewers | 2 | 7 | 78 | 72.0 | 4.38 | 1.33 | 72 | 31 | 8 | 9.00 | 3.88 |
| 2013 | Milwaukee Brewers | 1 | 1 | 25 | 24.2 | 1.09 | 1.05 | 26 | 9 | 2 | 9.49 | 3.28 |
| 2013 | Baltimore Orioles | 2 | 1 | 23 | 22.0 | 4.50 | 1.36 | 28 | 5 | 5 | 11.45 | 2.05 |
| 2013 | 3 | 2 | 48 | 46.2 | 2.70 | 1.20 | 54 | 14 | 7 | 10.41 | 2.70 |
| 2014 | Milwaukee Brewers | 5 | 5 | 69 | 68.0 | 3.04 | 0.99 | 73 | 18 | 14 | 9.66 | 2.38 |
| 2015 | Milwaukee Brewers | 1 | 3 | 60 | 57.0 | 2.21 | 0.86 | 62 | 11 | 6 | 9.79 | 1.74 |
| 2016 | Detroit Tigers | 3 | 4 | 61 | 58.1 | 3.24 | 1.13 | 52 | 21 | 6 | 8.02 | 3.24 |
| 2017 | Detroit Tigers | 2 | 5 | 28 | 25.1 | 7.82 | 1.66 | 23 | 11 | 9 | 8.17 | 3.91 |
| Career | — | 52 | 53 | 948 | 976.0 | 2.86 | 1.15 | 1,142 | 389 | 98 | 10.53 | 3.59 |
