| Year | Team | G | AB | H | HR | RBI | SB | BB | K | AVG | OBP | SLG | OPS |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2004 | Boston Red Sox | 72 | 208 | 54 | 7 | 35 | 0 | 33 | 45 | .260 | .367 | .413 |
| .780 |
| 2005 | Boston Red Sox | 44 | 79 | 22 | 1 | 9 | 0 | 14 | 19 | .278 | .400 | .405 | .805 |
| 2006 | Boston Red Sox | 147 | 569 | 159 | 13 | 72 | 5 | 91 | 120 | .279 | .381 | .429 | .810 |
| 2007 | Boston Red Sox | 145 | 528 | 152 | 16 | 83 | 4 | 77 | 105 | .288 | .390 | .453 | .843 |
| 2008 | Boston Red Sox | 145 | 538 | 168 | 29 | 115 | 3 | 62 | 108 | .312 | .390 | .569 | .959 |
| 2009 | Boston Red Sox | 136 | 491 | 150 | 27 | 94 | 7 | 77 | 125 | .305 | .413 | .548 | .961 |
| 2010 | Boston Red Sox | 102 | 362 | 111 | 19 | 62 | 4 | 58 | 67 | .307 | .411 | .564 | .975 |
| 2011 | Boston Red Sox | 120 | 431 | 111 | 17 | 80 | 3 | 68 | 100 | .258 | .373 | .459 | .832 |
| 2012 | Boston Red Sox | 42 | 146 | 34 | 4 | 14 | 0 | 14 | 39 | .233 | .315 | .377 | .692 |
| 2012 | Chicago White Sox | 80 | 292 | 69 | 15 | 46 | 0 | 37 | 69 | .236 | .346 | .425 | .771 |
| 2012 | 122 | 438 | 103 | 19 | 60 | 0 | 51 | 108 | .235 | .336 | .409 | .745 |
| 2013 | New York Yankees | 28 | 105 | 23 | 2 | 8 | 0 | 8 | 31 | .219 | .305 | .343 | .648 |
| Career | — | 1,061 | 3,749 | 1,053 | 150 | 618 | 26 | 539 | 828 | .281 | .382 | .478 | .860 |
