| Year | Team | G | AB | H | HR | RBI | SB | BB | K | AVG | OBP | SLG | OPS |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2007 | Oakland Athletics | 68 | 213 | 53 | 7 | 39 | 0 | 24 | 39 | .249 | .327 | .408 |
| .735 |
| 2008 | Oakland Athletics | 148 | 530 | 148 | 7 | 42 | 2 | 44 | 69 | .279 | .346 | .370 | .716 |
| 2009 | Oakland Athletics | 147 | 570 | 156 | 15 | 88 | 8 | 28 | 59 | .274 | .313 | .421 | .734 |
| 2010 | Oakland Athletics | 131 | 495 | 120 | 13 | 71 | 3 | 33 | 49 | .242 | .303 | .366 | .669 |
| 2011 | Oakland Athletics | 134 | 460 | 109 | 14 | 44 | 2 | 38 | 64 | .237 | .301 | .385 | .686 |
| 2012 | Oakland Athletics | 75 | 262 | 57 | 1 | 18 | 1 | 9 | 53 | .218 | .250 | .286 | .536 |
| 2012 | Washington Nationals | 43 | 146 | 39 | 5 | 25 | 1 | 11 | 20 | .267 | .321 | .404 | .725 |
| 2012 | 118 | 408 | 96 | 6 | 43 | 2 | 20 | 73 | .235 | .276 | .328 | .604 |
| 2013 | Washington Nationals | 79 | 252 | 56 | 3 | 25 | 2 | 20 | 32 | .222 | .283 | .310 | .593 |
| 2013 | Oakland Athletics | 15 | 33 | 10 | 2 | 7 | 0 | 2 | 3 | .303 | .343 | .545 | .888 |
| 2013 | 94 | 285 | 66 | 5 | 32 | 2 | 22 | 35 | .232 | .290 | .337 | .627 |
| 2014 | Minnesota Twins | 131 | 452 | 130 | 3 | 61 | 0 | 34 | 46 | .288 | .345 | .383 | .728 |
| 2015 | Minnesota Twins | 131 | 433 | 104 | 5 | 50 | 0 | 29 | 59 | .240 | .296 | .314 | .610 |
| 2016 | Minnesota Twins | 106 | 345 | 89 | 8 | 49 | 0 | 18 | 48 | .258 | .301 | .403 | .704 |
| 2017 | Atlanta Braves | 81 | 276 | 78 | 19 | 50 | 0 | 17 | 39 | .283 | .351 | .536 | .887 |
| 2018 | Atlanta Braves | 105 | 347 | 94 | 12 | 50 | 0 | 22 | 43 | .271 | .332 | .444 | .776 |
| 2019 | Washington Nationals | 85 | 280 | 74 | 17 | 63 | 0 | 20 | 36 | .264 | .324 | .486 | .810 |
| 2020 | Washington Nationals | 33 | 111 | 30 | 2 | 17 | 1 | 11 | 19 | .270 | .349 | .396 | .745 |
| 2021 | Los Angeles Angels | 72 | 219 | 49 | 6 | 16 | 0 | 12 | 44 | .224 | .294 | .342 | .636 |
| 2022 | Los Angeles Angels | 51 | 139 | 25 | 4 | 15 | 0 | 15 | 29 | .180 | .266 | .295 | .561 |
| Career | — | 1,635 | 5,563 | 1,421 | 143 | 730 | 20 | 387 | 751 | .255 | .314 | .388 | .702 |
