| Year | Team | W | L | G | IP | ERA | WHIP | K | BB | HR | K/9 | BB/9 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2008 | Pittsburgh Pirates | 0 | 1 | 15 | 15.0 | 6.60 | 1.93 | 16 | 9 | 2 | 9.60 | 5.40 |
| 2009 |
| Pittsburgh Pirates |
| 1 |
| 4 |
| 73 |
| 67.1 |
| 4.01 |
| 1.35 |
| 47 |
| 22 |
| 11 |
| 6.28 |
| 2.94 |
| 2010 | Atlanta Braves | 3 | 2 | 28 | 36.2 | 5.89 | 1.42 | 29 | 12 | 6 | 7.12 | 2.95 |
| 2010 | Kansas City Royals | 2 | 3 | 23 | 26.0 | 5.88 | 1.54 | 16 | 11 | 5 | 5.54 | 3.81 |
| 2010 | 5 | 5 | 51 | 62.2 | 5.89 | 1.47 | 45 | 23 | 11 | 6.46 | 3.30 |
| 2011 | Kansas City Royals | 0 | 0 | 4 | 7.2 | 10.57 | 2.22 | 8 | 5 | 3 | 9.39 | 5.87 |
| 2012 | Toronto Blue Jays | 1 | 1 | 9 | 21.1 | 8.44 | 1.64 | 27 | 10 | 6 | 11.39 | 4.22 |
| 2012 | Oakland Athletics | 0 | 0 | 4 | 3.1 | 18.90 | 3.00 | 3 | 1 | 1 | 8.10 | 2.70 |
| 2012 | 1 | 1 | 13 | 24.2 | 9.85 | 1.82 | 30 | 11 | 7 | 10.95 | 4.01 |
| 2013 | Oakland Athletics | 2 | 4 | 35 | 57.1 | 3.92 | 1.22 | 55 | 20 | 3 | 8.63 | 3.14 |
| 2014 | Oakland Athletics | 8 | 8 | 32 | 146.0 | 3.45 | 1.31 | 136 | 49 | 17 | 8.38 | 3.02 |
| 2015 | Oakland Athletics | 7 | 15 | 30 | 157.0 | 4.18 | 1.35 | 136 | 48 | 18 | 7.80 | 2.75 |
| 2016 | Toronto Blue Jays | 1 | 2 | 39 | 41.1 | 4.57 | 1.28 | 42 | 10 | 9 | 9.15 | 2.18 |
| 2016 | Los Angeles Dodgers | 1 | 0 | 23 | 25.2 | 4.21 | 1.40 | 21 | 8 | 3 | 7.36 | 2.81 |
| 2016 | 2 | 2 | 62 | 67.0 | 4.43 | 1.33 | 63 | 18 | 12 | 8.46 | 2.42 |
| 2017 | Los Angeles Angels | 7 | 11 | 38 | 138.0 | 5.35 | 1.40 | 119 | 45 | 28 | 7.76 | 2.93 |
| 2018 | Texas Rangers | 3 | 1 | 30 | 56.1 | 3.51 | 1.24 | 50 | 12 | 10 | 7.99 | 1.92 |
| 2018 | Chicago Cubs | 2 | 1 | 32 | 39.0 | 1.15 | 0.79 | 42 | 5 | 3 | 9.69 | 1.15 |
| 2018 | 5 | 2 | 62 | 95.1 | 2.55 | 1.06 | 92 | 17 | 13 | 8.69 | 1.60 |
| 2019 | Texas Rangers | 3 | 5 | 48 | 78.0 | 4.85 | 1.33 | 72 | 22 | 12 | 8.31 | 2.54 |
| 2020 | Texas Rangers | 0 | 0 | 18 | 17.0 | 6.88 | 1.59 | 13 | 7 | 6 | 6.88 | 3.71 |
| 2021 | Atlanta Braves | 3 | 2 | 30 | 33.2 | 2.14 | 1.01 | 36 | 11 | 0 | 9.62 | 2.94 |
| 2022 | Chicago Cubs | 0 | 0 | 3 | 5.2 | 6.35 | 1.59 | 3 | 2 | 1 | 4.76 | 3.18 |
| 2022 | Los Angeles Angels | 1 | 0 | 11 | 10.2 | 7.59 | 1.78 | 10 | 4 | 2 | 8.44 | 3.38 |
| 2022 | Atlanta Braves | 3 | 3 | 46 | 53.0 | 2.72 | 1.19 | 61 | 14 | 5 | 10.36 | 2.38 |
| 2022 | 4 | 3 | 60 | 69.1 | 3.76 | 1.31 | 74 | 20 | 8 | 9.61 | 2.60 |
| 2023 | Atlanta Braves | 1 | 0 | 36 | 34.2 | 1.56 | 1.10 | 39 | 12 | 2 | 10.13 | 3.12 |
| 2024 | Atlanta Braves | 2 | 2 | 46 | 63.1 | 3.13 | 1.25 | 55 | 19 | 10 | 7.82 | 2.70 |
| 2025 | Atlanta Braves | 0 | 1 | 4 | 8.0 | 9.00 | 2.38 | 8 | 5 | 4 | 9.00 | 5.63 |
| Career | — | 51 | 66 | 657 | 1142.0 | 4.27 | 1.33 | 1,044 | 363 | 167 | 8.23 | 2.86 |
