| Year | Team | G | AB | H | HR | RBI | SB | BB | K | AVG | OBP | SLG | OPS |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2006 | Toronto Blue Jays | 18 | 60 | 22 | 2 | 8 | 0 | 5 | 12 | .367 | .415 | .600 |
| 1.015 |
| 2007 | Toronto Blue Jays | 89 | 290 | 69 | 11 | 46 | 1 | 16 | 65 | .238 | .278 | .400 | .678 |
| 2008 | Toronto Blue Jays | 88 | 326 | 92 | 9 | 40 | 2 | 16 | 59 | .282 | .316 | .439 | .755 |
| 2009 | Toronto Blue Jays | 151 | 587 | 179 | 35 | 114 | 1 | 58 | 110 | .305 | .370 | .562 | .932 |
| 2010 | Toronto Blue Jays | 150 | 569 | 135 | 23 | 72 | 0 | 38 | 144 | .237 | .287 | .425 | .712 |
| 2011 | Toronto Blue Jays | 125 | 499 | 125 | 26 | 87 | 1 | 32 | 107 | .251 | .295 | .439 | .734 |
| 2012 | Toronto Blue Jays | 93 | 321 | 82 | 11 | 45 | 0 | 29 | 61 | .255 | .314 | .414 | .728 |
| 2013 | Toronto Blue Jays | 143 | 465 | 134 | 23 | 67 | 1 | 51 | 103 | .288 | .357 | .497 | .854 |
| 2014 | Toronto Blue Jays | 96 | 290 | 93 | 6 | 40 | 0 | 28 | 48 | .321 | .381 | .479 | .860 |
| 2015 | Milwaukee Brewers | 149 | 502 | 139 | 20 | 87 | 0 | 66 | 100 | .277 | .360 | .460 | .820 |
| 2016 | Seattle Mariners | 126 | 401 | 96 | 20 | 58 | 0 | 26 | 89 | .239 | .286 | .431 | .717 |
| 2017 | Washington Nationals | 116 | 267 | 81 | 14 | 59 | 1 | 28 | 47 | .303 | .362 | .513 | .875 |
| Career | — | 1,344 | 4,577 | 1,247 | 200 | 723 | 7 | 393 | 945 | .272 | .330 | .465 | .795 |
