| Year | Team | G | AB | H | HR | RBI | SB | BB | K | AVG | OBP | SLG | OPS |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2007 | Cleveland Indians | 45 | 159 | 45 | 3 | 22 | 0 | 17 | 29 | .283 | .354 | .421 |
| .775 |
| 2008 | Cleveland Indians | 114 | 352 | 91 | 6 | 47 | 4 | 46 | 77 | .259 | .346 | .366 | .712 |
| 2009 | Cleveland Indians | 131 | 523 | 161 | 6 | 68 | 17 | 44 | 89 | .308 | .361 | .438 | .799 |
| 2010 | Cleveland Indians | 97 | 381 | 105 | 3 | 29 | 6 | 25 | 60 | .276 | .326 | .346 | .672 |
| 2011 | Cleveland Indians | 151 | 604 | 165 | 25 | 92 | 17 | 44 | 119 | .273 | .332 | .460 | .792 |
| 2012 | Cleveland Indians | 143 | 555 | 150 | 16 | 68 | 9 | 52 | 99 | .270 | .338 | .423 | .761 |
| 2013 | Cleveland Indians | 136 | 508 | 123 | 14 | 64 | 9 | 35 | 114 | .242 | .299 | .402 | .701 |
| 2014 | Cleveland Indians | 97 | 378 | 93 | 9 | 40 | 7 | 27 | 79 | .246 | .305 | .386 | .691 |
| 2014 | Washington Nationals | 49 | 175 | 40 | 5 | 21 | 3 | 22 | 29 | .229 | .312 | .389 | .701 |
| 2014 | 146 | 553 | 133 | 14 | 61 | 10 | 49 | 108 | .241 | .307 | .387 | .694 |
| 2015 | Tampa Bay Rays | 143 | 505 | 134 | 15 | 58 | 6 | 36 | 107 | .265 | .315 | .430 | .745 |
| 2016 | New York Mets | 141 | 521 | 146 | 23 | 62 | 5 | 38 | 103 | .280 | .336 | .474 | .810 |
| 2017 | New York Mets | 135 | 479 | 134 | 14 | 59 | 3 | 50 | 83 | .280 | .351 | .434 | .785 |
| 2018 | New York Mets | 98 | 375 | 104 | 18 | 58 | 0 | 29 | 81 | .277 | .329 | .488 | .817 |
| 2018 | Philadelphia Phillies | 49 | 171 | 39 | 5 | 17 | 0 | 12 | 38 | .228 | .286 | .392 | .678 |
| 2018 | 147 | 546 | 143 | 23 | 75 | 0 | 41 | 119 | .262 | .316 | .458 | .774 |
| 2019 | Texas Rangers | 93 | 323 | 76 | 12 | 51 | 4 | 38 | 85 | .235 | .318 | .393 | .711 |
| 2019 | Washington Nationals | 38 | 124 | 40 | 6 | 40 | 0 | 19 | 18 | .323 | .404 | .565 | .969 |
| 2019 | 131 | 447 | 116 | 18 | 91 | 4 | 57 | 103 | .260 | .342 | .441 | .783 |
| 2020 | Washington Nationals | 52 | 190 | 46 | 8 | 31 | 0 | 19 | 40 | .242 | .305 | .447 | .752 |
| 2021 | Arizona Diamondbacks | 90 | 283 | 69 | 7 | 40 | 1 | 33 | 73 | .244 | .324 | .392 | .716 |
| 2021 | Cincinnati Reds | 20 | 26 | 2 | 0 | 2 | 0 | 3 | 7 | .077 | .194 | .077 | .271 |
| 2021 | 110 | 309 | 71 | 7 | 42 | 1 | 36 | 80 | .230 | .313 | .366 | .679 |
| Career | — | 1,822 | 6,632 | 1,763 | 195 | 869 | 91 | 589 | 1,330 | .266 | .329 | .423 | .752 |
