| Year | Team | G | AB | H | HR | RBI | SB | BB | K | AVG | OBP | SLG | OPS |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2005 | Cincinnati Reds | 18 | 38 | 10 | 1 | 2 | 1 | 6 | 9 | .263 | .364 | .421 |
| .785 |
| 2006 | Cincinnati Reds | 49 | 106 | 30 | 1 | 7 | 1 | 11 | 21 | .283 | .356 | .368 | .724 |
| 2008 | Oakland Athletics | 29 | 62 | 18 | 1 | 9 | 2 | 6 | 16 | .290 | .362 | .387 | .749 |
| 2009 | Oakland Athletics | 4 | 2 | 0 | 0 | 1 | 0 | 0 | 0 | .000 | .000 | .000 | .000 |
| 2010 | San Diego Padres | 99 | 284 | 77 | 9 | 36 | 8 | 27 | 51 | .271 | .335 | .433 | .768 |
| 2011 | San Diego Padres | 111 | 307 | 85 | 5 | 19 | 11 | 28 | 49 | .277 | .337 | .381 | .718 |
| 2012 | San Diego Padres | 130 | 348 | 102 | 8 | 36 | 13 | 27 | 52 | .293 | .345 | .451 | .796 |
| 2013 | San Diego Padres | 144 | 473 | 132 | 10 | 47 | 11 | 42 | 84 | .279 | .337 | .395 | .732 |
| 2014 | San Diego Padres | 89 | 248 | 60 | 1 | 16 | 8 | 18 | 51 | .242 | .293 | .319 | .612 |
| 2014 | Seattle Mariners | 32 | 82 | 16 | 2 | 5 | 1 | 7 | 19 | .195 | .256 | .317 | .573 |
| 2014 | 121 | 330 | 76 | 3 | 21 | 9 | 25 | 70 | .230 | .284 | .318 | .602 |
| 2015 | Chicago Cubs | 103 | 212 | 57 | 3 | 18 | 0 | 15 | 56 | .269 | .319 | .373 | .692 |
| Career | — | 808 | 2,162 | 587 | 41 | 196 | 56 | 187 | 408 | .272 | .330 | .392 | .722 |
