| Year | Team | G | AB | H | HR | RBI | SB | BB | K | AVG | OBP | SLG | OPS |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2010 | Minnesota Twins | 7 | 27 | 8 | 0 | 1 | 0 | 0 | 3 | .296 | .321 | .407 |
| .728 |
| 2010 | Washington Nationals | 15 | 52 | 14 | 1 | 4 | 0 | 2 | 9 | .269 | .296 | .404 | .700 |
| 2010 | 22 | 79 | 22 | 1 | 5 | 0 | 2 | 12 | .278 | .305 | .405 | .710 |
| 2011 | Washington Nationals | 113 | 389 | 104 | 15 | 52 | 0 | 38 | 76 | .267 | .334 | .445 | .779 |
| 2012 | Washington Nationals | 25 | 83 | 22 | 3 | 10 | 0 | 12 | 19 | .265 | .354 | .398 | .752 |
| 2013 | Washington Nationals | 78 | 287 | 78 | 16 | 59 | 0 | 15 | 42 | .272 | .307 | .470 | .777 |
| 2014 | Washington Nationals | 88 | 341 | 91 | 11 | 47 | 0 | 17 | 57 | .267 | .299 | .399 | .698 |
| 2015 | Washington Nationals | 128 | 475 | 109 | 15 | 68 | 0 | 21 | 101 | .229 | .258 | .358 | .616 |
| 2016 | Washington Nationals | 131 | 482 | 148 | 22 | 80 | 0 | 35 | 79 | .307 | .354 | .496 | .850 |
| 2017 | Tampa Bay Rays | 64 | 208 | 54 | 11 | 35 | 0 | 10 | 36 | .260 | .290 | .447 | .737 |
| 2018 | Tampa Bay Rays | 78 | 293 | 87 | 14 | 53 | 0 | 22 | 61 | .297 | .346 | .488 | .834 |
| 2018 | Philadelphia Phillies | 33 | 89 | 30 | 1 | 17 | 0 | 10 | 19 | .337 | .396 | .483 | .879 |
| 2018 | 111 | 382 | 117 | 15 | 70 | 0 | 32 | 80 | .306 | .358 | .487 | .845 |
| 2019 | New York Mets | 141 | 473 | 136 | 14 | 73 | 1 | 44 | 69 | .288 | .351 | .416 | .767 |
| 2020 | New York Mets | 45 | 142 | 34 | 5 | 15 | 0 | 10 | 31 | .239 | .297 | .387 | .684 |
| 2021 | Detroit Tigers | 35 | 120 | 24 | 6 | 13 | 0 | 6 | 29 | .200 | .238 | .392 | .630 |
| 2021 | Cleveland Indians | 9 | 31 | 7 | 2 | 7 | 0 | 3 | 7 | .226 | .286 | .419 | .705 |
| 2021 | 44 | 151 | 31 | 8 | 20 | 0 | 9 | 36 | .205 | .248 | .397 | .645 |
| Career | — | 990 | 3,492 | 946 | 136 | 534 | 1 | 245 | 638 | .271 | .318 | .432 | .750 |
