| Year | Team | W | L | G | IP | ERA | WHIP | K | BB | HR | K/9 | BB/9 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2010 | Houston Astros | 0 | 1 | 22 | 19.0 | 2.84 | 1.00 | 12 | 5 | 3 | 5.68 | 2.37 |
| 2011 |
| Houston Astros |
| 1 |
| 4 |
| 29 |
| 19.2 |
| 7.32 |
| 1.88 |
| 15 |
| 9 |
| 5 |
| 6.86 |
| 4.12 |
| 2012 | Houston Astros | 0 | 6 | 37 | 46.0 | 5.09 | 1.65 | 38 | 19 | 6 | 7.43 | 3.72 |
| 2013 | Washington Nationals | 0 | 3 | 39 | 37.2 | 3.35 | 1.38 | 32 | 10 | 3 | 7.65 | 2.39 |
| 2014 | Oakland Athletics | 2 | 4 | 69 | 57.1 | 1.57 | 0.85 | 51 | 15 | 4 | 8.01 | 2.35 |
| 2015 | Oakland Athletics | 2 | 2 | 62 | 47.2 | 4.15 | 1.34 | 45 | 19 | 11 | 8.50 | 3.59 |
| 2016 | Minnesota Twins | 1 | 4 | 39 | 34.0 | 2.65 | 1.21 | 29 | 14 | 2 | 7.68 | 3.71 |
| 2016 | Boston Red Sox | 0 | 2 | 18 | 12.2 | 6.39 | 1.66 | 12 | 8 | 2 | 8.53 | 5.68 |
| 2016 | 1 | 6 | 57 | 46.2 | 3.66 | 1.33 | 41 | 22 | 4 | 7.91 | 4.24 |
| 2017 | Boston Red Sox | 2 | 1 | 48 | 43.2 | 3.30 | 1.24 | 37 | 14 | 4 | 7.63 | 2.89 |
| 2019 | San Francisco Giants | 0 | 2 | 21 | 13.0 | 4.15 | 0.92 | 9 | 3 | 2 | 6.23 | 2.08 |
| 2021 | Baltimore Orioles | 0 | 0 | 16 | 17.2 | 5.60 | 1.70 | 10 | 7 | 1 | 5.09 | 3.57 |
| 2023 | Colorado Rockies | 1 | 0 | 6 | 6.1 | 4.26 | 2.21 | 2 | 3 | 2 | 2.84 | 4.26 |
| Career | — | 9 | 29 | 406 | 354.2 | 3.78 | 1.32 | 292 | 126 | 45 | 7.41 | 3.20 |
