| Year | Team | W | L | G | IP | ERA | WHIP | K | BB | HR | K/9 | BB/9 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2009 | Washington Nationals | 4 | 7 | 19 | 105.2 | 5.11 | 1.29 | 48 | 24 | 14 | 4.09 | 2.04 |
| 2010 |
| Washington Nationals |
| 4 |
| 4 |
| 35 |
| 128.0 |
| 5.13 |
| 1.50 |
| 85 |
| 41 |
| 13 |
| 5.98 |
| 2.88 |
| 2011 | Washington Nationals | 1 | 1 | 7 | 10.1 | 0.87 | 0.68 | 12 | 4 | 0 | 10.45 | 3.48 |
| 2012 | Washington Nationals | 6 | 1 | 59 | 88.1 | 2.34 | 1.20 | 87 | 36 | 7 | 8.86 | 3.67 |
| 2013 | Washington Nationals | 7 | 6 | 55 | 81.2 | 2.76 | 1.29 | 79 | 27 | 4 | 8.71 | 2.98 |
| 2014 | Washington Nationals | 4 | 5 | 49 | 72.2 | 3.84 | 1.27 | 56 | 14 | 5 | 6.94 | 1.73 |
| 2015 | Washington Nationals | 0 | 0 | 5 | 4.0 | 0.00 | 1.25 | 3 | 3 | 0 | 6.75 | 6.75 |
| 2017 | San Diego Padres | 2 | 3 | 60 | 80.1 | 3.14 | 1.20 | 74 | 28 | 12 | 8.29 | 3.14 |
| 2018 | San Diego Padres | 8 | 3 | 73 | 79.0 | 2.73 | 1.04 | 88 | 17 | 3 | 10.03 | 1.94 |
| 2019 | San Diego Padres | 8 | 7 | 76 | 82.0 | 3.29 | 1.16 | 73 | 15 | 13 | 8.01 | 1.65 |
| 2020 | San Diego Padres | 4 | 2 | 24 | 24.0 | 5.63 | 1.29 | 20 | 4 | 2 | 7.50 | 1.50 |
| 2021 | San Diego Padres | 6 | 3 | 67 | 88.1 | 3.06 | 1.04 | 83 | 13 | 13 | 8.46 | 1.32 |
| 2022 | San Diego Padres | 1 | 2 | 33 | 40.2 | 4.43 | 1.35 | 35 | 10 | 9 | 7.75 | 2.21 |
| Career | — | 55 | 44 | 562 | 885.0 | 3.66 | 1.24 | 743 | 236 | 95 | 7.56 | 2.40 |
