| Year | Team | G | AB | H | HR | RBI | SB | BB | K | AVG | OBP | SLG | OPS |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2008 | Chicago White Sox | 136 | 480 | 139 | 21 | 77 | 13 | 18 | 61 | .290 | .317 | .475 |
| .792 |
| 2009 | Chicago White Sox | 148 | 542 | 150 | 15 | 68 | 14 | 49 | 66 | .277 | .333 | .389 | .722 |
| 2010 | Chicago White Sox | 156 | 585 | 165 | 18 | 70 | 13 | 27 | 82 | .282 | .313 | .431 | .744 |
| 2011 | Chicago White Sox | 158 | 614 | 165 | 15 | 70 | 7 | 51 | 84 | .269 | .328 | .399 | .727 |
| 2012 | Chicago White Sox | 158 | 593 | 157 | 9 | 73 | 20 | 16 | 77 | .265 | .287 | .364 | .651 |
| 2013 | Chicago White Sox | 158 | 637 | 181 | 6 | 48 | 30 | 26 | 68 | .284 | .313 | .380 | .693 |
| 2014 | Chicago White Sox | 158 | 622 | 170 | 15 | 74 | 21 | 24 | 81 | .273 | .305 | .408 | .713 |
| 2015 | Chicago White Sox | 154 | 583 | 145 | 10 | 62 | 17 | 31 | 68 | .249 | .285 | .357 | .642 |
| 2016 | San Diego Padres | 128 | 421 | 101 | 5 | 41 | 6 | 17 | 56 | .240 | .275 | .330 | .605 |
| 2016 | Tampa Bay Rays | 17 | 57 | 14 | 1 | 7 | 2 | 4 | 7 | .246 | .295 | .351 | .646 |
| 2016 | 145 | 478 | 115 | 6 | 48 | 8 | 21 | 63 | .241 | .277 | .333 | .610 |
| Career | — | 1,371 | 5,134 | 1,387 | 115 | 590 | 143 | 263 | 650 | .270 | .307 | .392 | .699 |
