| Year | Team | W | L | G | IP | ERA | WHIP | K | BB | HR | K/9 | BB/9 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2010 | St. Louis Cardinals | 0 | 2 | 5 | 22.1 | 8.46 | 2.06 | 12 | 9 | 5 | 4.84 | 3.63 |
| 2012 |
| Colorado Rockies |
| 5 |
| 1 |
| 53 |
| 79.0 |
| 4.56 |
| 1.39 |
| 81 |
| 34 |
| 9 |
| 9.23 |
| 3.87 |
| 2013 | Colorado Rockies | 1 | 3 | 51 | 78.1 | 2.64 | 1.33 | 78 | 31 | 5 | 8.96 | 3.56 |
| 2014 | Colorado Rockies | 1 | 4 | 75 | 65.0 | 3.60 | 1.28 | 70 | 16 | 6 | 9.69 | 2.22 |
| 2015 | Colorado Rockies | 1 | 0 | 10 | 10.1 | 0.00 | 0.48 | 13 | 2 | 0 | 11.32 | 1.74 |
| 2016 | Colorado Rockies | 1 | 3 | 34 | 27.0 | 2.67 | 0.93 | 35 | 7 | 3 | 11.67 | 2.33 |
| 2017 | Colorado Rockies | 2 | 3 | 63 | 53.1 | 5.06 | 1.63 | 63 | 39 | 8 | 10.63 | 6.58 |
| 2018 | Colorado Rockies | 6 | 4 | 75 | 77.2 | 2.43 | 0.99 | 112 | 36 | 5 | 12.98 | 4.17 |
| 2019 | New York Yankees | 6 | 5 | 73 | 66.1 | 1.90 | 1.31 | 88 | 40 | 5 | 11.94 | 5.43 |
| 2020 | New York Yankees | 2 | 3 | 24 | 18.1 | 5.89 | 1.58 | 25 | 9 | 2 | 12.27 | 4.42 |
| 2021 | Boston Red Sox | 7 | 3 | 69 | 62.0 | 4.21 | 1.45 | 71 | 35 | 5 | 10.31 | 5.08 |
| 2022 | New York Mets | 6 | 3 | 66 | 65.2 | 2.06 | 0.97 | 79 | 16 | 6 | 10.83 | 2.19 |
| 2023 | New York Mets | 1 | 7 | 66 | 61.2 | 3.21 | 1.22 | 62 | 29 | 7 | 9.05 | 4.23 |
| 2024 | New York Mets | 2 | 2 | 60 | 56.0 | 4.34 | 1.29 | 70 | 23 | 6 | 11.25 | 3.70 |
| 2025 | New York Yankees | 0 | 0 | 3 | 1.2 | 0.00 | 2.40 | 3 | 4 | 0 | 16.20 | 21.60 |
| Career | — | 41 | 43 | 727 | 744.2 | 3.48 | 1.29 | 862 | 330 | 72 | 10.42 | 3.99 |
