| Year | Team | W | L | G | IP | ERA | WHIP | K | BB | HR | K/9 | BB/9 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2011 | Tampa Bay Rays | 1 | 0 | 3 | 9.1 | 2.89 | 1.29 | 15 | 3 | 1 | 14.46 | 2.89 |
| 2012 |
| Tampa Bay Rays |
| 11 |
| 11 |
| 31 |
| 177.1 |
| 3.81 |
| 1.35 |
| 175 |
| 81 |
| 18 |
| 8.88 |
| 4.11 |
| 2013 | Tampa Bay Rays | 17 | 4 | 27 | 150.1 | 3.29 | 1.30 | 143 | 76 | 14 | 8.56 | 4.55 |
| 2014 | Tampa Bay Rays | 0 | 2 | 2 | 10.0 | 2.70 | 1.50 | 6 | 5 | 1 | 5.40 | 4.50 |
| 2015 | Tampa Bay Rays | 3 | 4 | 12 | 63.0 | 5.43 | 1.54 | 46 | 23 | 9 | 6.57 | 3.29 |
| 2016 | Tampa Bay Rays | 7 | 7 | 21 | 130.0 | 4.08 | 1.27 | 109 | 40 | 20 | 7.55 | 2.77 |
| 2016 | San Francisco Giants | 6 | 5 | 12 | 68.1 | 4.08 | 1.33 | 69 | 32 | 5 | 9.09 | 4.21 |
| 2016 | 13 | 12 | 33 | 198.1 | 4.08 | 1.29 | 178 | 72 | 25 | 8.08 | 3.27 |
| 2017 | San Francisco Giants | 6 | 15 | 32 | 174.1 | 5.52 | 1.53 | 148 | 67 | 27 | 7.64 | 3.46 |
| 2018 | Texas Rangers | 3 | 8 | 39 | 102.0 | 6.79 | 1.66 | 86 | 41 | 19 | 7.59 | 3.62 |
| 2019 | Detroit Tigers | 0 | 0 | 2 | 10.0 | 0.00 | 0.40 | 9 | 1 | 0 | 8.10 | 0.90 |
| 2021 | Philadelphia Phillies | 2 | 4 | 24 | 73.0 | 6.29 | 1.59 | 63 | 38 | 15 | 7.77 | 4.68 |
| 2022 | Texas Rangers | 5 | 2 | 63 | 74.0 | 1.95 | 1.18 | 83 | 38 | 3 | 10.09 | 4.62 |
| 2023 | Los Angeles Angels | 4 | 1 | 41 | 44.0 | 2.66 | 1.02 | 49 | 12 | 6 | 10.02 | 2.45 |
| 2023 | Cleveland Guardians | 0 | 0 | 5 | 4.2 | 3.86 | 2.36 | 8 | 2 | 1 | 15.43 | 3.86 |
| 2023 | Miami Marlins | 1 | 0 | 4 | 4.0 | 0.00 | 1.25 | 3 | 1 | 0 | 6.75 | 2.25 |
| 2023 | 5 | 1 | 50 | 52.2 | 2.56 | 1.16 | 60 | 15 | 7 | 10.25 | 2.56 |
| 2024 | Los Angeles Angels | 5 | 3 | 51 | 48.1 | 5.03 | 1.34 | 41 | 26 | 11 | 7.63 | 4.84 |
| Career | — | 71 | 66 | 369 | 1142.2 | 4.39 | 1.39 | 1,053 | 486 | 150 | 8.29 | 3.83 |
