| Year | Team | W | L | G | IP | ERA | WHIP | K | BB | HR | K/9 | BB/9 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2011 | Minnesota Twins | 0 | 2 | 4 | 23.1 | 6.17 | 1.50 | 16 | 6 | 3 | 6.17 | 2.31 |
| 2012 | Minnesota Twins |
| 1 |
| 8 |
| 16 |
| 85.1 |
| 5.59 |
| 1.55 |
| 50 |
| 26 |
| 17 |
| 5.27 |
| 2.74 |
| 2013 | Minnesota Twins | 1 | 3 | 10 | 47.1 | 6.85 | 1.71 | 34 | 14 | 10 | 6.46 | 2.66 |
| 2014 | Toronto Blue Jays | 1 | 0 | 3 | 13.1 | 6.08 | 1.20 | 8 | 4 | 3 | 5.40 | 2.70 |
| 2014 | Kansas City Royals | 0 | 2 | 6 | 19.1 | 4.66 | 1.50 | 15 | 3 | 0 | 6.98 | 1.40 |
| 2014 | 2 teams | 1 | 2 | 9 | 32.2 | 5.23 | 1.38 | 23 | 7 | 3 | 6.34 | 1.93 |
| 2015 | Toronto Blue Jays | 5 | 0 | 58 | 64.2 | 2.92 | 1.08 | 71 | 11 | 3 | 9.88 | 1.53 |
| 2016 | Oakland Athletics | 0 | 4 | 53 | 64.2 | 3.76 | 1.28 | 71 | 14 | 6 | 9.88 | 1.95 |
| 2017 | Oakland Athletics | 4 | 2 | 70 | 64.0 | 4.22 | 1.25 | 78 | 23 | 7 | 10.97 | 3.23 |
| 2018 | Oakland Athletics | 0 | 1 | 25 | 24.0 | 4.13 | 1.46 | 22 | 10 | 3 | 8.25 | 3.75 |
| 2019 | Oakland Athletics | 4 | 4 | 75 | 85.0 | 1.80 | 0.96 | 124 | 21 | 5 | 13.13 | 2.22 |
| 2020 | Oakland Athletics | 3 | 1 | 24 | 25.1 | 1.78 | 0.67 | 37 | 3 | 1 | 13.14 | 1.07 |
| 2021 | Chicago White Sox | 8 | 3 | 69 | 71.0 | 2.54 | 0.73 | 113 | 7 | 11 | 14.32 | 0.89 |
| 2022 | Chicago White Sox | 4 | 4 | 58 | 57.2 | 2.81 | 1.04 | 85 | 16 | 7 | 13.27 | 2.50 |
| 2023 | Chicago White Sox | 2 | 0 | 5 | 5.0 | 5.40 | 1.00 | 3 | 1 | 1 | 5.40 | 1.80 |
| 2025 | Boston Red Sox | 0 | 2 | 14 | 13.2 | 6.59 | 1.39 | 12 | 7 | 2 | 7.90 | 4.61 |
| Career | — | 33 | 36 | 490 | 663.2 | 3.88 | 1.20 | 739 | 166 | 79 | 10.02 | 2.25 |
