| Year | Team | W | L | G | IP | ERA | WHIP | K | BB | HR | K/9 | BB/9 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2013 | Pittsburgh Pirates | 10 | 7 | 19 | 117.1 | 3.22 | 1.17 | 100 | 28 | 7 | 7.67 | 2.15 |
| 2014 | Pittsburgh Pirates |
| 11 |
| 5 |
| 22 |
| 138.0 |
| 3.65 |
| 1.21 |
| 138 |
| 40 |
| 11 |
| 9.00 |
| 2.61 |
| 2015 | Pittsburgh Pirates | 19 | 8 | 32 | 208.0 | 2.60 | 1.09 | 202 | 44 | 11 | 8.74 | 1.90 |
| 2016 | Pittsburgh Pirates | 7 | 10 | 21 | 116.0 | 3.88 | 1.44 | 98 | 36 | 7 | 7.60 | 2.79 |
| 2017 | Pittsburgh Pirates | 12 | 12 | 33 | 203.0 | 4.26 | 1.25 | 196 | 55 | 31 | 8.69 | 2.44 |
| 2018 | Houston Astros | 15 | 5 | 32 | 200.1 | 2.88 | 1.03 | 276 | 64 | 19 | 12.40 | 2.88 |
| 2019 | Houston Astros | 20 | 5 | 33 | 212.1 | 2.50 | 0.89 | 326 | 48 | 29 | 13.82 | 2.03 |
| 2020 | New York Yankees | 7 | 3 | 12 | 73.0 | 2.84 | 0.96 | 94 | 17 | 14 | 11.59 | 2.10 |
| 2021 | New York Yankees | 16 | 8 | 30 | 181.1 | 3.23 | 1.06 | 243 | 41 | 24 | 12.06 | 2.03 |
| 2022 | New York Yankees | 13 | 8 | 33 | 200.2 | 3.50 | 1.02 | 257 | 50 | 33 | 11.53 | 2.24 |
| 2023 | New York Yankees | 15 | 4 | 33 | 209.0 | 2.63 | 0.98 | 222 | 48 | 20 | 9.56 | 2.07 |
| 2024 | New York Yankees | 8 | 5 | 17 | 95.0 | 3.41 | 1.13 | 99 | 29 | 11 | 9.38 | 2.75 |
| Career | — | 153 | 80 | 317 | 1954.0 | 3.18 | 1.09 | 2,251 | 500 | 217 | 10.37 | 2.30 |
