| Year | Team | W | L | G | IP | ERA | WHIP | K | BB | HR | K/9 | BB/9 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2012 | Arizona Diamondbacks | 1 | 2 | 4 | 16.1 | 6.06 | 1.65 | 17 | 13 | 2 | 9.37 | 7.16 |
| 2013 |
| Cleveland Indians |
| 1 |
| 2 |
| 4 |
| 17.0 |
| 5.29 |
| 1.82 |
| 11 |
| 16 |
| 3 |
| 5.82 |
| 8.47 |
| 2014 | Cleveland Indians | 5 | 8 | 26 | 153.0 | 4.18 | 1.38 | 143 | 60 | 16 | 8.41 | 3.53 |
| 2015 | Cleveland Indians | 11 | 12 | 31 | 176.0 | 4.55 | 1.31 | 170 | 79 | 23 | 8.69 | 4.04 |
| 2016 | Cleveland Indians | 12 | 8 | 35 | 190.0 | 4.26 | 1.31 | 168 | 70 | 20 | 7.96 | 3.32 |
| 2017 | Cleveland Indians | 17 | 9 | 32 | 176.1 | 4.19 | 1.37 | 196 | 60 | 25 | 10.00 | 3.06 |
| 2018 | Cleveland Indians | 12 | 6 | 28 | 175.1 | 2.21 | 1.09 | 221 | 57 | 9 | 11.34 | 2.93 |
| 2019 | Cleveland Indians | 9 | 8 | 24 | 156.2 | 3.79 | 1.21 | 185 | 63 | 22 | 10.63 | 3.62 |
| 2019 | Cincinnati Reds | 2 | 5 | 10 | 56.1 | 6.39 | 1.35 | 68 | 19 | 12 | 10.86 | 3.04 |
| 2019 | 11 | 13 | 34 | 213.0 | 4.48 | 1.25 | 253 | 82 | 34 | 10.69 | 3.46 |
| 2020 | Cincinnati Reds | 5 | 4 | 11 | 73.0 | 1.73 | 0.79 | 100 | 17 | 9 | 12.33 | 2.10 |
| 2021 | Los Angeles Dodgers | 8 | 5 | 17 | 107.2 | 2.59 | 1.00 | 137 | 37 | 19 | 11.45 | 3.09 |
| Career | — | 83 | 69 | 222 | 1297.2 | 3.79 | 1.24 | 1,416 | 491 | 160 | 9.82 | 3.41 |
