| Year | Team | W | L | G | IP | ERA | WHIP | K | BB | HR | K/9 | BB/9 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2012 | St. Louis Cardinals | 1 | 0 | 6 | 13.2 | 1.32 | 0.95 | 16 | 4 | 0 | 10.54 | 2.63 |
| 2013 |
| St. Louis Cardinals |
| 15 |
| 9 |
| 31 |
| 173.1 |
| 3.06 |
| 1.21 |
| 169 |
| 57 |
| 20 |
| 8.78 |
| 2.96 |
| 2014 | St. Louis Cardinals | 10 | 9 | 32 | 183.0 | 3.74 | 1.27 | 127 | 73 | 22 | 6.25 | 3.59 |
| 2015 | Atlanta Braves | 6 | 17 | 33 | 205.1 | 3.02 | 1.25 | 171 | 73 | 13 | 7.50 | 3.20 |
| 2016 | Arizona Diamondbacks | 3 | 12 | 20 | 101.0 | 6.15 | 1.67 | 70 | 42 | 14 | 6.24 | 3.74 |
| 2017 | Arizona Diamondbacks | 2 | 2 | 4 | 22.0 | 4.09 | 1.45 | 20 | 12 | 1 | 8.18 | 4.91 |
| 2018 | Arizona Diamondbacks | 0 | 4 | 5 | 16.0 | 10.69 | 2.00 | 19 | 8 | 5 | 10.69 | 4.50 |
| 2019 | Texas Rangers | 1 | 3 | 19 | 44.0 | 8.59 | 1.98 | 30 | 29 | 8 | 6.14 | 5.93 |
| 2021 | Chicago Cubs | 0 | 0 | 3 | 2.0 | 31.50 | 6.00 | 1 | 5 | 0 | 4.50 | 22.50 |
| 2021 | Pittsburgh Pirates | 0 | 1 | 10 | 10.2 | 5.06 | 1.41 | 7 | 6 | 3 | 5.91 | 5.06 |
| 2021 | 0 | 1 | 13 | 12.2 | 9.24 | 2.13 | 8 | 11 | 3 | 5.68 | 7.82 |
| 2022 | San Francisco Giants | 0 | 1 | 4 | 7.0 | 6.43 | 1.29 | 14 | 3 | 0 | 18.00 | 3.86 |
| 2023 | Los Angeles Dodgers | 3 | 0 | 36 | 42.0 | 1.71 | 0.90 | 42 | 19 | 3 | 9.00 | 4.07 |
| 2024 | Detroit Tigers | 6 | 8 | 51 | 55.2 | 4.53 | 0.97 | 49 | 13 | 9 | 7.92 | 2.10 |
| 2025 | Arizona Diamondbacks | 3 | 3 | 37 | 36.1 | 1.98 | 0.96 | 40 | 11 | 3 | 9.91 | 2.72 |
| 2025 | Milwaukee Brewers | 1 | 0 | 11 | 9.2 | 5.59 | 1.34 | 14 | 4 | 2 | 13.03 | 3.72 |
| 2025 | 4 | 3 | 48 | 46.0 | 2.74 | 1.04 | 54 | 15 | 5 | 10.57 | 2.93 |
| Career | — | 51 | 69 | 302 | 921.2 | 4.04 | 1.31 | 789 | 359 | 103 | 7.70 | 3.51 |
