| Year | Team | W | L | G | IP | ERA | WHIP | K | BB | HR | K/9 | BB/9 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2012 | Houston Astros | 3 | 8 | 16 | 85.1 | 5.27 | 1.55 | 38 | 39 | 14 | 4.01 | 4.11 |
| 2013 |
| Houston Astros |
| 6 |
| 10 |
| 31 |
| 153.2 |
| 5.15 |
| 1.54 |
| 123 |
| 52 |
| 20 |
| 7.20 |
| 3.05 |
| 2014 | Houston Astros | 12 | 9 | 29 | 200.0 | 2.93 | 1.18 | 146 | 48 | 11 | 6.57 | 2.16 |
| 2015 | Houston Astros | 20 | 8 | 33 | 232.0 | 2.48 | 1.02 | 216 | 51 | 17 | 8.38 | 1.98 |
| 2016 | Houston Astros | 9 | 12 | 26 | 168.0 | 4.55 | 1.29 | 144 | 48 | 20 | 7.71 | 2.57 |
| 2017 | Houston Astros | 14 | 5 | 23 | 145.2 | 2.90 | 1.12 | 125 | 47 | 15 | 7.72 | 2.90 |
| 2018 | Houston Astros | 12 | 11 | 34 | 204.2 | 3.74 | 1.31 | 153 | 58 | 18 | 6.73 | 2.55 |
| 2019 | Atlanta Braves | 8 | 8 | 19 | 112.2 | 3.75 | 1.37 | 91 | 39 | 16 | 7.27 | 3.12 |
| 2020 | Chicago White Sox | 6 | 2 | 11 | 63.1 | 1.99 | 1.09 | 42 | 17 | 2 | 5.97 | 2.42 |
| 2021 | Chicago White Sox | 9 | 9 | 32 | 162.0 | 5.28 | 1.53 | 95 | 59 | 25 | 5.28 | 3.28 |
| 2022 | Chicago White Sox | 2 | 5 | 8 | 32.0 | 7.88 | 2.16 | 20 | 20 | 6 | 5.63 | 5.63 |
| 2022 | Arizona Diamondbacks | 0 | 2 | 4 | 18.2 | 9.64 | 1.82 | 18 | 7 | 4 | 8.68 | 3.38 |
| 2022 | Texas Rangers | 0 | 2 | 2 | 10.0 | 12.60 | 2.20 | 7 | 4 | 1 | 6.30 | 3.60 |
| 2022 | 2 | 9 | 14 | 60.2 | 9.20 | 2.06 | 45 | 31 | 11 | 6.68 | 4.60 |
| 2023 | Minnesota Twins | 2 | 1 | 10 | 37.2 | 5.97 | 1.67 | 25 | 18 | 3 | 5.97 | 4.30 |
| 2024 | Milwaukee Brewers | 0 | 0 | 4 | 16.2 | 5.40 | 1.86 | 11 | 8 | 3 | 5.94 | 4.32 |
| Career | — | 103 | 92 | 282 | 1642.1 | 4.04 | 1.33 | 1,254 | 515 | 175 | 6.87 | 2.82 |
