| Year | Team | W | L | G | IP | ERA | WHIP | K | BB | HR | K/9 | BB/9 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2016 | Pittsburgh Pirates | 1 | 1 | 7 | 12.2 | 7.82 | 1.89 | 11 | 5 | 4 | 7.82 | 3.55 |
| 2017 |
| Pittsburgh Pirates |
| 7 |
| 9 |
| 31 |
| 150.1 |
| 4.07 |
| 1.31 |
| 117 |
| 52 |
| 14 |
| 7.00 |
| 3.11 |
| 2018 | Pittsburgh Pirates | 14 | 10 | 31 | 170.2 | 3.11 | 1.18 | 126 | 55 | 15 | 6.64 | 2.90 |
| 2019 | Pittsburgh Pirates | 7 | 9 | 26 | 145.2 | 5.38 | 1.41 | 113 | 44 | 27 | 6.98 | 2.72 |
| 2020 | Pittsburgh Pirates | 2 | 8 | 11 | 55.1 | 6.18 | 1.57 | 49 | 21 | 15 | 7.97 | 3.42 |
| 2021 | Chicago Cubs | 4 | 2 | 13 | 58.2 | 5.06 | 1.53 | 61 | 22 | 10 | 9.36 | 3.38 |
| 2021 | New York Mets | 0 | 0 | 10 | 32.1 | 3.06 | 1.42 | 29 | 9 | 1 | 8.07 | 2.51 |
| 2021 | 4 | 2 | 23 | 91.0 | 4.35 | 1.49 | 90 | 31 | 11 | 8.90 | 3.07 |
| 2022 | New York Mets | 3 | 5 | 30 | 89.2 | 3.21 | 1.23 | 84 | 23 | 12 | 8.43 | 2.31 |
| 2023 | Washington Nationals | 6 | 10 | 30 | 144.1 | 5.55 | 1.60 | 111 | 53 | 34 | 6.92 | 3.30 |
| 2024 | Washington Nationals | 6 | 1 | 13 | 66.2 | 2.03 | 1.04 | 59 | 18 | 3 | 7.97 | 2.43 |
| 2025 | Washington Nationals | 3 | 10 | 17 | 82.2 | 6.21 | 1.54 | 65 | 21 | 11 | 7.08 | 2.29 |
| Career | — | 53 | 65 | 219 | 1009.0 | 4.46 | 1.38 | 825 | 323 | 146 | 7.36 | 2.88 |
