| Year | Team | W | L | G | IP | ERA | WHIP | K | BB | HR | K/9 | BB/9 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2014 | Philadelphia Phillies | 1 | 0 | 1 | 1.0 | 0.00 | 0.00 | 1 | 0 | 0 | 9.00 | 0.00 |
| 2015 |
| Philadelphia Phillies |
| 2 |
| 2 |
| 32 |
| 40.1 |
| 3.79 |
| 1.19 |
| 41 |
| 10 |
| 8 |
| 9.15 |
| 2.23 |
| 2016 | Philadelphia Phillies | 4 | 4 | 79 | 80.1 | 2.58 | 1.11 | 102 | 30 | 9 | 11.43 | 3.36 |
| 2017 | Philadelphia Phillies | 4 | 5 | 74 | 74.2 | 3.01 | 1.26 | 86 | 26 | 9 | 10.37 | 3.13 |
| 2018 | Philadelphia Phillies | 1 | 3 | 53 | 47.2 | 5.10 | 1.30 | 76 | 16 | 11 | 14.35 | 3.02 |
| 2019 | Philadelphia Phillies | 3 | 6 | 68 | 67.2 | 2.93 | 1.02 | 89 | 24 | 10 | 11.84 | 3.19 |
| 2020 | Philadelphia Phillies | 2 | 2 | 24 | 21.2 | 4.57 | 1.71 | 27 | 13 | 0 | 11.22 | 5.40 |
| 2021 | Philadelphia Phillies | 4 | 7 | 74 | 74.1 | 3.63 | 1.17 | 98 | 32 | 12 | 11.87 | 3.87 |
| 2022 | Houston Astros | 6 | 4 | 70 | 65.1 | 3.72 | 1.01 | 79 | 17 | 3 | 10.88 | 2.34 |
| 2023 | Houston Astros | 6 | 3 | 71 | 68.1 | 1.71 | 1.05 | 77 | 31 | 7 | 10.14 | 4.08 |
| 2024 | Chicago Cubs | 8 | 4 | 46 | 44.0 | 3.89 | 1.52 | 46 | 26 | 4 | 9.41 | 5.32 |
| 2024 | Houston Astros | 2 | 1 | 16 | 15.1 | 4.70 | 1.04 | 18 | 2 | 4 | 10.57 | 1.17 |
| 2024 | 10 | 5 | 62 | 59.1 | 4.10 | 1.40 | 64 | 28 | 8 | 9.71 | 4.25 |
| 2025 | Atlanta Braves | 0 | 1 | 2 | 1.0 | 45.00 | 6.00 | 1 | 1 | 1 | 9.00 | 9.00 |
| 2025 | Los Angeles Angels | 3 | 0 | 21 | 14.0 | 5.14 | 1.29 | 19 | 7 | 2 | 12.21 | 4.50 |
| 2025 | Houston Astros | 0 | 1 | 12 | 11.2 | 5.40 | 1.80 | 15 | 8 | 3 | 11.57 | 6.17 |
| 2025 | 3 | 2 | 35 | 26.2 | 6.75 | 1.69 | 35 | 16 | 6 | 11.81 | 5.40 |
| Career | — | 46 | 43 | 643 | 627.1 | 3.47 | 1.20 | 775 | 243 | 83 | 11.12 | 3.49 |
