| Year | Team | G | AB | H | HR | RBI | SB | BB | K | AVG | OBP | SLG | OPS |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2012 | Arizona Diamondbacks | 22 | 85 | 22 | 2 | 5 | 2 | 14 | 15 | .259 | .382 | .412 |
| .794 |
| 2013 | Arizona Diamondbacks | 66 | 250 | 63 | 3 | 22 | 5 | 17 | 44 | .252 | .314 | .360 | .674 |
| 2014 | Chicago White Sox | 123 | 486 | 146 | 1 | 35 | 15 | 43 | 83 | .300 | .362 | .401 | .763 |
| 2015 | Chicago White Sox | 153 | 610 | 175 | 14 | 56 | 18 | 58 | 131 | .287 | .361 | .431 | .792 |
| 2016 | Chicago White Sox | 157 | 619 | 176 | 14 | 59 | 14 | 63 | 115 | .284 | .362 | .428 | .790 |
| 2017 | Washington Nationals | 23 | 91 | 27 | 2 | 13 | 3 | 14 | 18 | .297 | .393 | .462 | .855 |
| 2018 | Washington Nationals | 95 | 319 | 96 | 5 | 33 | 9 | 38 | 64 | .301 | .394 | .411 | .805 |
| 2019 | Washington Nationals | 151 | 566 | 158 | 15 | 49 | 15 | 65 | 106 | .279 | .365 | .428 | .793 |
| 2020 | Washington Nationals | 41 | 159 | 36 | 4 | 17 | 3 | 12 | 32 | .226 | .285 | .384 | .669 |
| 2021 | Chicago White Sox | 58 | 189 | 38 | 5 | 28 | 2 | 20 | 55 | .201 | .298 | .344 | .642 |
| 2021 | Los Angeles Angels | 26 | 65 | 13 | 1 | 2 | 1 | 2 | 16 | .200 | .232 | .277 | .509 |
| 2021 | 84 | 254 | 51 | 6 | 30 | 3 | 22 | 71 | .201 | .282 | .327 | .609 |
| Career | — | 915 | 3,439 | 950 | 66 | 319 | 87 | 346 | 679 | .276 | .354 | .409 | .763 |
