| Year | Team | W | L | G | IP | ERA | WHIP | K | BB | HR | K/9 | BB/9 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2016 | Cleveland Indians | 3 | 3 | 17 | 53.0 | 5.26 | 1.49 | 50 | 29 | 8 | 8.49 | 4.92 |
| 2017 |
| Cleveland Indians |
| 12 |
| 6 |
| 27 |
| 121.2 |
| 3.11 |
| 1.25 |
| 137 |
| 60 |
| 13 |
| 10.13 |
| 4.44 |
| 2018 | Cleveland Indians | 13 | 8 | 32 | 200.0 | 3.02 | 1.16 | 207 | 67 | 21 | 9.32 | 3.02 |
| 2019 | Cleveland Indians | 13 | 4 | 21 | 126.0 | 2.71 | 1.06 | 169 | 37 | 10 | 12.07 | 2.64 |
| 2020 | Cleveland Indians | 1 | 1 | 4 | 22.2 | 3.18 | 1.37 | 21 | 11 | 5 | 8.34 | 4.37 |
| 2020 | San Diego Padres | 2 | 1 | 4 | 19.0 | 2.84 | 0.89 | 19 | 3 | 1 | 9.00 | 1.42 |
| 2020 | 3 | 2 | 8 | 41.2 | 3.02 | 1.15 | 40 | 14 | 6 | 8.64 | 3.02 |
| 2022 | San Diego Padres | 7 | 7 | 23 | 114.1 | 4.33 | 1.20 | 91 | 35 | 20 | 7.16 | 2.76 |
| 2023 | Chicago White Sox | 9 | 9 | 24 | 131.1 | 3.77 | 1.23 | 110 | 40 | 16 | 7.54 | 2.74 |
| 2024 | Chicago White Sox | 0 | 3 | 4 | 16.0 | 6.75 | 1.94 | 15 | 9 | 4 | 8.44 | 5.06 |
| 2025 | Chicago White Sox | 0 | 2 | 8 | 5.2 | 7.94 | 2.29 | 3 | 8 | 0 | 4.76 | 12.71 |
| Career | — | 60 | 44 | 164 | 809.2 | 3.55 | 1.22 | 822 | 299 | 98 | 9.14 | 3.32 |
