| Year | Team | W | L | G | IP | ERA | WHIP | K | BB | HR | K/9 | BB/9 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2016 | Houston Astros | 4 | 4 | 11 | 62.0 | 4.06 | 1.21 | 55 | 16 | 9 | 7.98 | 2.32 |
| 2017 |
| Houston Astros |
| 7 |
| 8 |
| 38 |
| 109.1 |
| 4.77 |
| 1.33 |
| 98 |
| 28 |
| 18 |
| 8.07 |
| 2.30 |
| 2018 | Pittsburgh Pirates | 6 | 9 | 19 | 115.1 | 4.06 | 1.18 | 100 | 23 | 12 | 7.80 | 1.79 |
| 2019 | Pittsburgh Pirates | 11 | 12 | 32 | 170.1 | 4.44 | 1.22 | 157 | 39 | 21 | 8.30 | 2.06 |
| 2020 | Pittsburgh Pirates | 1 | 5 | 8 | 39.2 | 3.86 | 1.24 | 55 | 16 | 5 | 12.48 | 3.63 |
| 2021 | San Diego Padres | 11 | 9 | 32 | 181.1 | 3.18 | 1.08 | 203 | 54 | 22 | 10.08 | 2.68 |
| 2022 | San Diego Padres | 10 | 7 | 30 | 181.0 | 2.93 | 1.08 | 184 | 42 | 22 | 9.15 | 2.09 |
| 2023 | San Diego Padres | 10 | 3 | 17 | 97.1 | 3.05 | 1.14 | 97 | 21 | 10 | 8.97 | 1.94 |
| 2024 | San Diego Padres | 6 | 5 | 19 | 99.2 | 3.88 | 1.17 | 101 | 23 | 14 | 9.12 | 2.08 |
| Career | — | 66 | 62 | 206 | 1056.0 | 3.73 | 1.17 | 1,050 | 262 | 133 | 8.95 | 2.23 |
