| Year | Team | W | L | G | IP | ERA | WHIP | K | BB | HR | K/9 | BB/9 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2015 | Toronto Blue Jays | 0 | 2 | 13 | 12.1 | 4.38 | 1.70 | 12 | 6 | 2 | 8.76 | 4.38 |
| 2015 |
| Colorado Rockies |
| 0 |
| 1 |
| 5 |
| 5.1 |
| 10.13 |
| 1.88 |
| 6 |
| 4 |
| 2 |
| 10.13 |
| 6.75 |
| 2015 | 0 | 3 | 18 | 17.2 | 6.11 | 1.75 | 18 | 10 | 4 | 9.17 | 5.09 |
| 2016 | Colorado Rockies | 0 | 0 | 19 | 14.2 | 6.14 | 1.57 | 12 | 5 | 3 | 7.36 | 3.07 |
| 2017 | Baltimore Orioles | 3 | 3 | 39 | 66.1 | 3.53 | 1.22 | 38 | 28 | 8 | 5.16 | 3.80 |
| 2018 | Baltimore Orioles | 2 | 7 | 63 | 86.1 | 3.96 | 1.45 | 57 | 50 | 9 | 5.94 | 5.21 |
| 2019 | Baltimore Orioles | 1 | 3 | 65 | 73.1 | 4.66 | 1.42 | 71 | 41 | 10 | 8.71 | 5.03 |
| 2020 | Baltimore Orioles | 1 | 0 | 16 | 15.2 | 4.02 | 1.40 | 24 | 5 | 3 | 13.79 | 2.87 |
| 2020 | New York Mets | 1 | 2 | 10 | 9.0 | 4.00 | 2.11 | 14 | 8 | 1 | 14.00 | 8.00 |
| 2020 | 2 | 2 | 26 | 24.2 | 4.01 | 1.66 | 38 | 13 | 4 | 13.86 | 4.74 |
| 2021 | New York Mets | 3 | 4 | 69 | 70.1 | 3.45 | 1.29 | 77 | 43 | 7 | 9.85 | 5.50 |
| 2022 | New York Yankees | 5 | 0 | 34 | 29.0 | 4.03 | 1.45 | 31 | 15 | 2 | 9.62 | 4.66 |
| 2023 | Arizona Diamondbacks | 6 | 6 | 75 | 64.2 | 4.31 | 1.18 | 60 | 25 | 8 | 8.35 | 3.48 |
| 2024 | Arizona Diamondbacks | 0 | 0 | 11 | 13.2 | 5.93 | 1.68 | 8 | 3 | 3 | 5.27 | 1.98 |
| 2025 | Chicago White Sox | 0 | 0 | 6 | 6.0 | 7.50 | 1.67 | 4 | 5 | 1 | 6.00 | 7.50 |
| Career | — | 22 | 28 | 425 | 466.2 | 4.24 | 1.39 | 414 | 238 | 59 | 7.98 | 4.59 |
